In 2015, Margaret Gonzalez and Steve Perdicaris founded an El-Sistema inspired after-school music education program in San Francisco's Mission District for underserved children. Held at the Mission Cultural Center for Latino Arts, the program includes approximately 60 classes from September through May with instruction in basic musicianship, violin and cello. In 2020, student enrollment reached nearly 50 children ages 7-14. For the 2020-21 school year, all classes are being held virtually.
In 2020, Music Mission San Francisco became a 501(c)3) charitable corporation.